inflammation in diabetes RESEARCH LAB

 
 

Please explore our website to learn more about our research interests, recent publications, and information on how to join our group.


Recent news:

Congratulations to Sam for being awarded a CIHR Transplant Research Training Award for 2013-2015!


Congratulations to Dominika for being awarded a prestigious CIHR Vanier Canada Graduate Scholarship from 2013-2016!


Welcome Samuel Chow to our research group! Sam will be starting his Master’s degree in September 2012.


Congratulations to Dominika for receiving a PhD salary award from the CIHR Transplant Research Training Program!


Overview:

Blood glucose levels must be tightly controlled in the human body. The hormones INSULIN and GLUCAGON are the principle regulators of blood glucose. The pancreatic islet is the main production site of circulating INSULIN and GLUCAGON in the human body.


After a meal, insulin is secreted from the pancreatic beta cell to allow our body to take up energy in the form of glucose. When we are not eating, glucagon is secreted by the pancreatic alpha cell to mobilize glucose from the liver to other organs that require it as an energy source. This counter-regulatory system maintains blood glucose in a homeostatic range, allowing our bodies to function normally.


Diabetes mellitus is a disease characterized by elevated, uncontrolled blood glucose levels. Both type 1 and type 2 diabetes mellitus are caused by insufficient insulin production by the pancreatic beta cell. In addition, patients with both types 1 and type 2 diabetes suffer from dysfunctional glucagon secretion from the pancreatic alpha cell, worsening their blood glucose control. The incidence of diabetes is increasing globally at a staggering rate, with devastating human, social, and economic impact.


Research in the EHSES LAB is focussed on how inflammation regulates metabolism, and how this impacts glucose homeostasis; a new field of research recently coined “IMMUNO-METABOLISM”. We are specifically concentrating on how the inflammatory response leads to both pancreatic beta and alpha cell malfunction in diabetes. We hope that by gathering information on islet biology and pathophysiology we can help cure diabetes mellitus in the near future.


Location:

The Ehses lab is located in the brand new Child & Family Research Institute, associated with BC Children’s Hospital and the University of British Columbia, in beautiful Vancouver, Canada.







 

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